ASM events
This conference is managed by the American Society for Microbiology

Abrahamsen, Lee

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Abrahamsen.jpg

Bates College

labraham@bates.edu

207-786-8266

http://www.bates.edu/biology/research/lee-abrahamsen/

Outline - we will overlay course objectives onto this

 

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Protein Structure/Function

 

What do we want them to know?

 

1) That proteins are made of amino acids strung together in a linear sequence.

2) What an amino acid is

3) That amino acids can be categorized (acidic, basic, uncharged polar, non-polar)

4) What a peptide bond is

5) What primary, secondary, tertiary, quaternary stuctures are

6) Other molecules in proteins (zinc, iron, chloride)

7) Protein/Protein interactions: quaternary structure

8) Protein domains

9) Protein families (evolution, related functions, different structures)

10)How protein function is regulated

            multiple binding sites

            phosphorylation

            nucleotide binding –hydrolysis

            proteolytic cleavage

 

 

 

 

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Warm up questions:

 

Concepts 1-5

 

 

 

 

 

Lecture info

 

Bonds that create secondary/tertiary structure

Alpha helices, beta sheets, structure/function based on chemistry

 

In class Activity

 

Pipecleaner Activity – different color pipecleaners represent different folding patterns, put them together to make a whole protein, compare proteins between groups.  Product is the protein. 

 

Assessment:

 

Clicker questions to assess whether they are beginning to apply the basic knowledge: 

 

What could happen to the function of this protein if you changed the amino acids in X region of this protein?

 

What would happen if you heated up this protein and broke all the hydrogen bonds?

 

Lecture info:

 

6,7

 

Quaternary Structure

Other molecules

Homodimers, heterodimers

 

Assessment:

 

Clicker questions:

 

Case studies – sickle cell, oxygen binding, how does the structure of the protein lead to the disease or something

 

Lecture info:

 

8,9

 

Lecture info:

 

10

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